Medical Disclaimer:
The contents of this article are based on the reported experiences of individuals who have used lithium orotate. However, it is crucial to understand that these accounts are anecdotal and do not constitute medical advice. The information provided herein should not be interpreted as a substitute for professional medical guidance, diagnosis, or treatment. Lithium orotate, like any other supplement or medication, should only be used under the supervision and guidance of a qualified healthcare provider. Every individual’s response to lithium orotate may vary, and its effects can differ based on factors such as medical history, current medications, and overall health status.
Lithium orotate and L-theanine together are gaining attention for their potential benefits in mental health and mood disorders. Lithium orotate is a compound of elemental lithium and orotic acid available as a dietary supplement. Unlike prescription lithium carbonate or lithium citrate, which are approved for bipolar disorder and other mental health conditions, lithium orotate has not been evaluated by the FDA for medical treatment. L-theanine, an amino acid found in tea, is known for its calming effects on brain cells and its role in reducing stress and anxiety.
Some individuals use this combination for mood support, sleep, and cognitive function, though more research is needed to confirm its effectiveness. Understanding their potential risks, including adverse effects on kidney function and thyroid health, is essential before considering this combination as part of a lithium treatment or supplement regimen.
What is Lithium Orotate?
Lithium orotate is a dietary supplement that combines elemental lithium with orotic acid. Unlike prescription lithium salts such as lithium carbonate and lithium citrate, which are used in lithium therapy for bipolar disorder and other mental disorders, lithium orotate is available in low doses as an over-the-counter supplement.
It is commonly used for mood stabilization, anxiety management, and brain health. Some suggest it may have neuroprotective and antioxidant effects, but more research is needed to determine its full benefits and safety.
Potential Benefits of Lithium Orotate
Lithium orotate is sometimes used as a supplement for brain health, though research on its effects is limited. Some studies suggest it could offer beneficial effects for mental health, but further research is needed.
- Mood stabilization – May help with mood disorders such as depression and anxiety.
- Reduced anxiety and stress – Could promote relaxation and emotional balance.
- Neuroprotective effects – May support brain cells and cognitive function.
- Potential role in addiction recovery – Some research suggests it may assist in managing drug addictions.
- Low-dose alternative to prescription lithium – Provides lithium in smaller doses without the need for a prescription.
Possible Side Effects of Lithium Orotate
Lithium orotate is considered a low-dose alternative to prescription lithium, but adverse effects can still occur. Proper dosage is essential to avoid toxicity and protect kidney function.
- Nausea and digestive issues – Can cause stomach discomfort in some individuals.
- Dizziness and fatigue – May affect energy levels and concentration.
- Dry mouth and increased thirst – Lithium-related symptoms reported in some patients.
- Kidney and thyroid concerns – Long-term use of lithium compounds, including lithium orotate, may impact kidney function and thyroid health.
- Possible toxicity at higher doses – Excessive intake can lead to toxic effects, similar to prescription lithium treatment.

What is L-Theanine?
L-Theanine is an amino acid found primarily in green tea leaves and is known for its calming effects on the brain. It’s commonly taken to support relaxation and focus, though individual responses may vary, and it is commonly used for stress reduction, improved focus, and better sleep. L-theanine influences neurotransmitters like glutamate, helping to regulate mood and cognitive function. Some studies suggest it may support mental health by reducing symptoms of anxiety and improving concentration.
Potential Benefits of L-Theanine
L-theanine is widely used for relaxation and cognitive support. It may provide several mental health benefits, especially when combined with other supplements.
- Reduced anxiety and stress – Helps lower stress levels by promoting relaxation.
- Improved sleep quality – May support better sleep without causing grogginess.
- Enhanced focus and cognitive function – Can improve concentration and mental clarity.
- Potential antioxidant effects – May help protect brain cells from oxidative stress.
Possible Side Effects of L-Theanine
L-theanine is generally well-tolerated and has a low risk of side effects when taken in appropriate doses. However, some individuals may experience mild reactions.
- Headaches – Some users report mild headaches.
- Gastrointestinal discomfort – Can cause stomach upset in sensitive individuals.
- Lower blood pressure – May slightly reduce blood pressure, which could affect those with existing conditions.
L-theanine is considered safe when taken in proper amounts, but consulting a doctor before combining it with other medications or supplements is recommended.

Can You Take Lithium Orotate and L-Theanine Together?
Lithium orotate and L-theanine together may offer complementary benefits for mood stabilization and anxiety relief. Lithium orotate, known for its role in supporting mental disorders like bipolar disorder and depression, works as a mood stabilizer, while L-theanine promotes relaxation by affecting neurotransmitters like glutamate.
Their combined effects may help reduce stress, improve emotional balance, and support brain health. While both are considered safe in low doses, potential interactions with medications or underlying health conditions should be considered. Higher doses of lithium orotate may lead to adverse effects, including kidney function concerns, so consulting a doctor before combining these supplements is essential.
What to Consider Before Combining Them
Lithium orotate and L-theanine may provide beneficial effects, but individual responses vary. Consulting a healthcare provider can help determine the right approach based on personal health needs.
- Existing health conditions – Those with kidney, thyroid, or mood disorders should seek medical advice before use.
- Current medications – Lithium treatment or other prescription medications may interact with these supplements.
- Individual tolerance levels – Sensitivity to lithium salts or amino acids like L-theanine varies among individuals.
- Appropriate dosage – Taking a low dose of lithium orotate reduces the risk of toxicity.
- Long-term effects – More research is needed to determine the safety of prolonged use.
Benefits of Taking Lithium Orotate and L-Theanine Together
Combining lithium orotate and L-theanine may provide additional benefits beyond taking them separately. Their effects on mood, cognitive function, and sleep make them an interesting combination for mental well-being.
Synergistic Effects on Mood and Relaxation
Lithium orotate is sometimes used as a supplement for mood support, but its effects are not well studied. Meanwhile, L-theanine promotes relaxation without sedation.
Some believe this combination supports brain function and relaxation, though clinical evidence is limited. Some individuals report feeling calmer when taking this combination, but there is insufficient clinical evidence to confirm its effectiveness for conditions like bipolar disorder or PTSD.
Potential Cognitive Benefits
L-theanine is linked to improved focus and cognitive function, while lithium orotate supports brain health and may protect against neurodegeneration. They may enhance mental clarity, support concentration, and reduce stress-related cognitive decline. This combination could be beneficial for individuals experiencing brain fog, chronic stress, or ADHD symptoms.
Improved Sleep Quality
Anxiety and mood disorders can interfere with sleep, leading to insomnia and poor rest. Some people take lithium orotate and L-theanine to support mood and relaxation, possibly contributing to better sleep. However, more research is needed.
Some studies suggest that L-theanine increases alpha brain waves, encouraging a calm state that supports deeper sleep. Taking these supplements together could benefit individuals struggling with stress-related sleep disturbances.

Risks and Side Effects of Combining Lithium Orotate and L-Theanine
Taking lithium orotate and L-theanine together may offer benefits, but there are potential risks. Lithium orotate, even in low doses, can lead to lithium toxicity if taken in excess, affecting kidney function and thyroid health. L-theanine is generally well-tolerated, but some individuals may experience mild side effects.
Possible Side Effects
- Drowsiness and fatigue – May cause excessive relaxation, affecting energy levels.
- Dizziness or lightheadedness – Can occur, especially when standing up too quickly.
- Gastrointestinal issues – Some individuals may experience nausea or stomach discomfort.
- Dry mouth and increased thirst – A common effect of lithium supplementation.
- Risk of lithium toxicity – Higher doses of lithium orotate may lead to toxic effects, similar to prescription lithium treatment.
Who Should Avoid This Combination?
Certain individuals should avoid taking lithium orotate and L-theanine together due to potential health risks. Pregnant and breastfeeding women should not take lithium supplements due to possible effects on fetal development. Children should only take lithium under medical supervision, as their bodies may respond differently to lithium salts.
Those with kidney disease, thyroid disorders, or cardiovascular conditions should avoid lithium orotate because of its potential impact on kidney function and sodium balance. Individuals taking prescription lithium should consult their doctor before considering additional lithium supplements to avoid potential interactions.
How to Safely Take Lithium Orotate and L-Theanine Together
Taking lithium orotate and L-theanine together should be done carefully to avoid adverse effects. Lithium orotate supplements are available in various dosages, and individuals should consult a healthcare provider to determine appropriate use. However, a very common starting dose for lithium orotate is between 5 mg and 10 mg of elemental lithium per day, while L-theanine is often taken in doses of 100 mg to 200 mg per day.
Starting with the lowest effective dose and gradually adjusting as needed can help minimize risks. Individuals with existing health conditions or prescription medications should speak with their doctor before using this combination.
Tips for Safe Use
Taking these supplements correctly can help maximize benefits while reducing potential risks.
- Start with a low dose – Avoid higher doses initially to monitor how the body responds.
- Monitor for side effects – Watch for symptoms like dizziness, nausea, or excessive drowsiness.
- Stay hydrated – Lithium can affect sodium levels, so proper hydration is essential.
- Keep a symptom journal – Tracking mood, sleep, and side effects can help determine effectiveness.
- Avoid other lithium-containing supplements – Prevents excessive lithium intake and reduces toxicity risk.

What to Discuss with Your Doctor
Before combining lithium orotate and L-theanine, discussing personal health conditions with a doctor is important. Individuals taking prescription lithium therapy for bipolar disorder, depression, or psychosis should ask if supplementing with lithium orotate is safe. Those with kidney disease, thyroid disorders, or cardiovascular issues need medical guidance to determine if lithium supplementation is appropriate.
Doctors can also help assess potential interactions with medications, including antidepressants, antipsychotics, and mood stabilizers. Proper medical supervision ensures this combination is safe and effective for individual health needs.
Alternatives to Taking Lithium Orotate and L-Theanine Together
Lithium orotate and L-theanine are not the only options for managing mood and anxiety. Other supplements and lifestyle changes may provide similar benefits without the need for combination therapy.
Other Supplements for Anxiety and Mood
Several other supplements may help with mood stabilization, stress reduction, and cognitive function.
- Magnesium – Supports brain health, reduces anxiety, and promotes relaxation.
- Ashwagandha – An adaptogen that helps the body manage stress and balance cortisol levels.
- 5-HTP – A precursor to serotonin that may support mood and sleep quality.
- GABA – A neurotransmitter that promotes relaxation and reduces anxiety symptoms.
- Rhodiola Rosea – An adaptogenic herb that may improve focus and combat stress-related fatigue.
Non-Supplement Approaches
Lifestyle changes can play a key role in managing anxiety and mood disorders. Regular exercise has been shown to reduce stress and boost endorphins, improving overall mood. Meditation and mindfulness practices help regulate emotions and promote relaxation by reducing activity in the brain’s stress centers.
Therapy, including cognitive behavioral therapy (CBT), can provide tools to manage anxiety and mood disorders effectively. Improving sleep hygiene, reducing caffeine intake, and maintaining a balanced diet can also support mental well-being. These natural strategies can be used alongside or instead of supplements for a holistic approach to mental health.
Should You Take Lithium Orotate and L-Theanine Together?
Lithium orotate and L-theanine may benefit mood stabilization, anxiety reduction, and cognitive function. Lithium orotate is marketed as a dietary supplement containing lithium, but it is not an approved alternative to prescription lithium therapy treatment, while L-theanine promotes relaxation without sedation. When taken together, they may enhance mood and sleep quality, but potential risks, including lithium toxicity and kidney function concerns, must be considered.
Consulting a doctor before use, starting with a low dose, and monitoring for adverse effects can help ensure safety. Alternative supplements and lifestyle changes may also support mental health without the need for combination therapy.
Frequently Asked Questions
Is It Safe to Drive While Taking Lithium Orotate and L-Theanine Together?
Lithium orotate and L-theanine may cause drowsiness or dizziness in some individuals, so it’s best to assess personal tolerance before driving.
Can This Combination Help with Sleep Disorders?
Lithium orotate may support mood stabilization, while L-theanine promotes relaxation, potentially benefiting sleep quality.
Are There Any Foods or Drinks to Avoid While Taking These Supplements?
Reducing caffeine and alcohol intake may help prevent interactions that could affect sleep, anxiety, or mood stability.
How Long Does It Take to See Effects?
Effects vary by individual, but some may notice improvements in mood and relaxation within a few days to a few weeks of consistent use.
Should I Take Lithium Orotate and L-Theanine with Other Medications?
Consulting a doctor is essential before combining these supplements with prescription medications, especially those for bipolar disorder, depression, or anxiety.
References
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- Mauer, S., Vergne, D., & Ghaemi, S. N. (2014). Standard and trace-dose lithium: a systematic review of dementia prevention and other behavioral benefits. The Australian and New Zealand journal of psychiatry, 48(9), 809–818. https://doi.org/10.1177/0004867414536932
- Nathan, P. J., Lu, K., Gray, M., & Oliver, C. (2006). The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. Journal of herbal pharmacotherapy, 6(2), 21–30. https://pubmed.ncbi.nlm.nih.gov/17182482/
- Nobre, A. C., Rao, A., & Owen, G. N. (2008). L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pacific journal of clinical nutrition, 17 Suppl 1, 167–168. https://pubmed.ncbi.nlm.nih.gov/18296328/
- Szklarska, D., & Rzymski, P. (2019). Is Lithium a Micronutrient? From Biological Activity and Epidemiological Observation to Food Fortification. Biological trace element research, 189(1), 18–27. https://doi.org/10.1007/s12011-018-1455-2






